An amber snow warning has been issued for the northern and central England and will be in effect from 3pm today until midday on Friday.
The warning covers an area from the south of the Peak District up to the North Pennines.
The Met Office says 10-20cm of snow is likely to fall across much of the area, with 30-40cm in some places, and will be accompanied by strong winds.
There is likely to be “significant disruption” to transport, power lines and mobile phone network coverage, with heavy snow, strong easterly winds and blizzards predicted.
The alert affects Derbyshire, Durham, Cheshire East, Cumbria, Greater Manchester, Lancashire, Staffordshire, along with North, South and West Yorkshire.
Elsewhere, yellow weather warnings for snow and ice covering northeast England, a large part of central England and Wales are in place until 7am today.
A snow and ice warning for northern Scotland is in place until 10am.
Meanwhile, a separate yellow weather warning for snow covering vast swathes of the country is also in place between 7am today and 2pm tomorrow.